Asymmetric nitroaldol reaction using nitromethane labeled with C-11
2008 (English)In: Tetrahedron Letters, ISSN 0040-4039, Vol. 49, no 41, 5837-5839 p.Article in journal (Refereed) Published
Nitro [C-11]methane produced from [C-11]O-2 reacted with several aldehydes in the presence of chiral metal catalyst prepared from LaLi3(tris(binaphtoxide)), n-BuLi, H2O, and (R)-binaphtol. The Molar ratios of La, Li, and binaphtol for effective catalysis in the C-11-labeling were 1/4/4.5 and 1/4/6, respectively. The C-11-nitroaldol products were obtained in 3-25% radiochemical yields with 39-51 % ee within 20 min starting from the preparation of nitro[C-11]methane.
Place, publisher, year, edition, pages
2008. Vol. 49, no 41, 5837-5839 p.
IdentifiersURN: urn:nbn:se:uu:diva-107882DOI: 10.1016/j.tetlet.2008.07.074ISI: 000259595100001OAI: oai:DiVA.org:uu-107882DiVA: diva2:233427