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The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease
Dept. of Microbiology, Tumor and Cell Biology (MTC), Karolinska Inst., Stockholm, Sweden.
Dept. of Microbiology, Tumor and Cell Biology (MTC), Karolinska Inst., Stockholm, Sweden.
Dept. of Microbiology, Tumor and Cell Biology (MTC), Karolinska Inst., Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
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2009 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 106, no 29, 11966-11971 p.Article in journal (Refereed) Published
Abstract [en]

Deletion or mutation of the SAP gene is associated with the X-linked lymphoproliferative disease (XLP) that is characterized by extreme sensitivity to Epstein-Barr virus (EBV). Primary infection of the affected individuals leads to serious, sometimes fatal infectious mononucleosis (IM) and proneness to lymphoma. Our present results revealed a proapoptotic function of SAP by which it contributes to the maintenance of T-cell homeostasis and to the elimination of potentially dangerous DNA-damaged cells. Therefore, the loss of this function could be responsible for the uncontrolled T-cell proliferation in fatal IM and for the generation of lymphomas. We show now the role of SAP in apoptosis in T and B lymphocyte-derived lines. Among the clones of T-ALL line, the ones with higher SAP levels succumbed more promptly to activation induced cell death (AICD). Importantly, introduction of SAP expression into lymphoblastoid cell lines (LCL) established from XLP patients led to elevated apoptotic response to DNA damage. Similar results were obtained in the osteosarcoma line, Saos-2. We have shown that the anti-apoptotic protein VCP (valosin-containing protein) binds to SAP, suggesting that it could be instrumental in the enhanced apoptotic response modulated by SAP.

Place, publisher, year, edition, pages
2009. Vol. 106, no 29, 11966-11971 p.
Keyword [en]
activation induced cell death, apoptosis, lymphomas, p53
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-108459DOI: 10.1073/pnas.0905691106ISI: 000268178400029OAI: oai:DiVA.org:uu-108459DiVA: diva2:235943
Available from: 2009-09-18 Created: 2009-09-18 Last updated: 2017-12-13Bibliographically approved

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