A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma.
2006 (English)In: Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, E-ISSN 1873-264X, Vol. 41, no 1, 207-212 p.Article in journal (Refereed) Published
A stability study for amodiaquine (AQ) and desethylamodiaquine (AQm) in whole blood and plasma is reported. AQ, AQm and chloroquine (CQ) were simultaneously analysed and the ratios AQ/CQ and AQm/CQ were used to ensure correct interpretation of the stability results. CQ was stable in whole blood and plasma at all tested temperatures enabling it to be a stability marker in stability studies. Simultaneous analysis of compounds, of which at least one is already known to be stable, permits a within sample ratio to be used as a stability indicator. The new approach significantly reduced bias when compared to the traditional approach. AQ and AQm were stable in plasma at -86 degrees C and -20 degrees C for 35 days, at 4 degrees C for 14 days and at 22 degrees C for 1 day. AQ and AQm were stable in blood at -86 degrees C and 4 degrees C for 35 days, at -20 degrees C and 22 degrees C for 7 days and at 37 degrees C for 1 day.
Place, publisher, year, edition, pages
2006. Vol. 41, no 1, 207-212 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-108744DOI: 10.1016/j.jpba.2005.10.018ISI: 000236655100028PubMedID: 16307860OAI: oai:DiVA.org:uu-108744DiVA: diva2:240690