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A new mechanism of blood vessel growth - hope for new treatment strategies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
2009 (English)In: Discovery medicine, ISSN 1539-6509, Vol. 8, no 40, 23-27 p.Article in journal (Refereed) Published
Abstract [en]

Growth of new blood vessels (angiogenesis) is essential for embryo development as well as for wound healing and progression of a number of diseases such as cancer, inflammatory conditions, eye diseases, psoriasis, and rheumatoid arthritis in the adult. Current paradigms explain blood vessel growth entirely by sprouting angiogenesis or by vessel splitting through so called intussusceptive angiogenesis. However, these mechanisms are mainly derived from experiments on the developing embryo while less is known about angiogenesis in the adult during, e.g., wound healing, tumor growth, and inflammation. Recently we showed that blood vessel growth in the adult can be induced and directed by mechanical forces that naturally develop during healing or remodeling of tissues. In contrast to sprouting and intussusception, the new biomechanical hypothesis assumes that functional blood vessels are passively translocated which, if found generic, may drastically change the approach for developing anti- and pro-angiogenic therapies in the treatment of a variety of diseases.

Place, publisher, year, edition, pages
2009. Vol. 8, no 40, 23-27 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-108928PubMedID: 19772838OAI: oai:DiVA.org:uu-108928DiVA: diva2:241626
Available from: 2009-10-05 Created: 2009-10-05 Last updated: 2011-06-30Bibliographically approved

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Gerwins, Pär

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