uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Both cyclooxygenase- and cytokine-mediated inflammation are associated with carotid intima-media thickness
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Show others and affiliations
2007 (English)In: Cytokine, ISSN 1043-4666, E-ISSN 1096-0023, Vol. 38, no 3, 130-136 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Common carotid artery intima-media thickness (CCA-IMT) is a valid index of atherosclerosis, which is viewed as an inflammatory disease. It is unknown if various modes of inflammation (cyclooxygenase [COX]-mediated, cytokine-mediated), oxidative stress and anti-oxidants are independently related to CCA-IMT. METHODS AND RESULTS: We investigated cross-sectional relations between CCA-IMT measured by B-mode ultrasound and COX-mediated inflammation (as measured by 15-keto-dihydro-prostaglandin F(2alpha) [PGF(2alpha)], cytokine-mediated inflammation (interleukin-6 [IL-6], high sensitivity C-reactive protein [hsCRP] and serum amyloid A protein [SAA]), oxidative stress (8-iso-PGF(2alpha), an F(2)-isoprostane; a non-enzymatic, free radical-induced product of arachidonic acid), and tocopherols (anti-oxidants) in a small subset of a population-based sample of elderly men (n=234) stating no use of anti-inflammatory medications. In a backward-stepwise regression analysis of correlates of CCA-IMT (with PGF(2alpha), hsCRP, IL-6, SAA, F(2)-isoprostanes, tocopherols, diabetes, body mass index (BMI), beta-blocker, statin treatment, smoking, hypertension and cholesterol), PGF(2alpha), CRP, beta-blocker treatment, diabetes and BMI were independently associated with CCA-IMT. There were no associations between F(2)-isoprostanes or tocopherols and CCA-IMT in this study. CONCLUSION: This study suggests both COX- and cytokine-mediated inflammation to be independently associated with increased CCA-IMT, implying that there might be more than one mode of inflammation involved in atherogenesis.

Place, publisher, year, edition, pages
2007. Vol. 38, no 3, 130-136 p.
Keyword [en]
Prostaglandins, Isoprostanes, Inflammation, Intima–media, Ultrasound
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-108956DOI: 10.1016/j.cyto.2007.05.014ISI: 000249474300003PubMedID: 17644349OAI: oai:DiVA.org:uu-108956DiVA: diva2:241708
Available from: 2009-10-05 Created: 2009-10-05 Last updated: 2017-12-13Bibliographically approved
In thesis
1. Carotid Vessel Wall Thickness and Echogenicity: In the ULSAM study
Open this publication in new window or tab >>Carotid Vessel Wall Thickness and Echogenicity: In the ULSAM study
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In this thesis the common carotid artery intima media thickness in nearly 500 elderly men is independently associated with insulin sensitivity, measured by the gold standard hyperinsulinemic euglycemic clamp test (paper 1), to both COX- and cytokine mediated inflammation independently of other markers of inflammation, oxidative stress and antioxidant status (paper 2) and also to the alleles of the apolipoprotein gene independently of lipid levels and cardiovascular risk factors (paper 3). The echogenicity of the carotid intima-media complex measured as grey scale median predicts mortality independently of common carotid artery intima-media thickness, prior cardiovascular disease and cardiovascular risk factors (paper 4).

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2008. 106 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 332
Keyword
Medicine, Epidemiology, Medicin
Identifiers
urn:nbn:se:uu:diva-8642 (URN)978-91-554-7161-3 (ISBN)
Public defence
2008-05-09, Robergsalen, ingång 40 plan 4, Akademiska sjukhuset, Uppsala, 13:15 (English)
Opponent
Supervisors
Available from: 2008-04-25 Created: 2008-04-25 Last updated: 2009-10-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Larsson, AndersAndrén, Bertil

Search in DiVA

By author/editor
Larsson, AndersAndrén, Bertil
By organisation
Department of Public Health and Caring SciencesClinical Nutrition and MetabolismDepartment of Medical SciencesGeriatrics
In the same journal
Cytokine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 429 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf