Both cyclooxygenase- and cytokine-mediated inflammation are associated with carotid intima-media thickness
2007 (English)In: Cytokine, ISSN 1043-4666, E-ISSN 1096-0023, Vol. 38, no 3, 130-136 p.Article in journal (Refereed) Published
BACKGROUND: Common carotid artery intima-media thickness (CCA-IMT) is a valid index of atherosclerosis, which is viewed as an inflammatory disease. It is unknown if various modes of inflammation (cyclooxygenase [COX]-mediated, cytokine-mediated), oxidative stress and anti-oxidants are independently related to CCA-IMT. METHODS AND RESULTS: We investigated cross-sectional relations between CCA-IMT measured by B-mode ultrasound and COX-mediated inflammation (as measured by 15-keto-dihydro-prostaglandin F(2alpha) [PGF(2alpha)], cytokine-mediated inflammation (interleukin-6 [IL-6], high sensitivity C-reactive protein [hsCRP] and serum amyloid A protein [SAA]), oxidative stress (8-iso-PGF(2alpha), an F(2)-isoprostane; a non-enzymatic, free radical-induced product of arachidonic acid), and tocopherols (anti-oxidants) in a small subset of a population-based sample of elderly men (n=234) stating no use of anti-inflammatory medications. In a backward-stepwise regression analysis of correlates of CCA-IMT (with PGF(2alpha), hsCRP, IL-6, SAA, F(2)-isoprostanes, tocopherols, diabetes, body mass index (BMI), beta-blocker, statin treatment, smoking, hypertension and cholesterol), PGF(2alpha), CRP, beta-blocker treatment, diabetes and BMI were independently associated with CCA-IMT. There were no associations between F(2)-isoprostanes or tocopherols and CCA-IMT in this study. CONCLUSION: This study suggests both COX- and cytokine-mediated inflammation to be independently associated with increased CCA-IMT, implying that there might be more than one mode of inflammation involved in atherogenesis.
Place, publisher, year, edition, pages
2007. Vol. 38, no 3, 130-136 p.
Prostaglandins, Isoprostanes, Inflammation, Intima–media, Ultrasound
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-108956DOI: 10.1016/j.cyto.2007.05.014ISI: 000249474300003PubMedID: 17644349OAI: oai:DiVA.org:uu-108956DiVA: diva2:241708