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Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: An association study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2008 (English)In: American journal of medical genetics. Part B, Neuropsychiatric genetics, ISSN 1552-4841, Vol. 147B, no 6, 976-982 p.Article in journal (Refereed) Published
Abstract [en]

Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs, C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia case-control samples. In addition, Norwegian patients with bipolar disorder were investigated. There were no statistically significant allele or genotype case-control differences. The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. However, when combined with previous studies in meta-analyses there is still evidence for association between the MTHFR C677T polymorphism. and schizophrenia. Additional studies are warranted to shed further light on these relationships. (c) 2007 Wiley-Liss, Inc.

Place, publisher, year, edition, pages
2008. Vol. 147B, no 6, 976-982 p.
Keyword [en]
methylenetetrahydrofolate reductase gene (MTHFR), SNPs, meta-analysis, schizophrenia, bipolar disorder
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-109066DOI: 10.1002/ajmg.b.30671ISI: 000259050100042PubMedID: 18165967OAI: oai:DiVA.org:uu-109066DiVA: diva2:248770
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2009-10-14Bibliographically approved

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