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Dissection of the genetic architecture of body weight in chicken reveals the impact of epistasis on domestication traits
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, The Linnaeus Centre for Bioinformatics.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, The Linnaeus Centre for Bioinformatics.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, The Linnaeus Centre for Bioinformatics.ORCID iD: 0000-0002-2722-5264
2008 (English)In: Genetics, ISSN 0016-6731, E-ISSN 1943-2631, Vol. 179, no 3, 1591-1599 p.Article in journal (Refereed) Published
Abstract [en]

In this contribution, we study the genetic mechanisms leading to differences in the observed growth patterns of domesticated White Leghorn chickens and their wild ancestor the red jungle fowl. An epistatic QTL analysis for several body-weight measures from hatch to adulthood confirms earlier findings that polymorphisms at > , 15 loci contribute to body-weight determination in an F-2 intercross between these populations and that many loci are involved in complex genetic interactions. Here, we use a new genetic model to decompose the genetic effects of this multilocus epistatic genetic network. The results show how the functional modeling of genetic effects provides new insights into how genetic interactions in a large set of loci jointly contribute to phenotypic expression. By exploring the functional effects of QTL allels, we show that some alleles can display temporal shifts in the expression of genetic effects due to their dependencies on the genetic background. Our results demonstrate that the effects of many genes are dependent on genetic interactions with other loci and how their involvement in the domestication process relies on these interactions.

Place, publisher, year, edition, pages
2008. Vol. 179, no 3, 1591-1599 p.
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-109129DOI: 10.1534/genetics.108.089300ISI: 000258313400037OAI: oai:DiVA.org:uu-109129DiVA: diva2:248935
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13

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Carlborg, Örjan

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