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Assembly of polypeptide-functionalized gold nanoparticles through a heteroassociation- and folding-dependent bridging
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry.
2008 (English)In: Nano letters (Print), ISSN 1530-6984, Vol. 8, no 8, 2473-2478 p.Article in journal (Refereed) Published
Abstract [en]

Gold nanoparticles were functionalized with a synthetic polypeptide, de novo-designed to associate with a charge complementary linker polypeptide in a folding-dependent manner. A heterotrimeric complex that folds into two disulphide-linked four-helix bundles is formed when the linker polypeptide associates with two of the immobilized peptides. The heterotrimer forms in between separate particles and induces a rapid and extensive aggregation with a well-defined interpartide spacing. The aggregated particles are redispersed when the disulphide bridge in the linker polypeptide is reduced.

Place, publisher, year, edition, pages
2008. Vol. 8, no 8, 2473-2478 p.
National Category
Chemical Sciences
URN: urn:nbn:se:uu:diva-109140DOI: 10.1021/nl8014796ISI: 000258440700063OAI: oai:DiVA.org:uu-109140DiVA: diva2:248955
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2009-10-09Bibliographically approved

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