Use of perfluoro groups in nucleophilic 18F-fluorination
2010 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 53, no 1, 24-30 p.Article in journal (Refereed) Published
Substrates with leaving groups that contained perfluoro moieties were investigated in labelling chemistry in order to exploit their properties to improve reactivity and purification. [F-18] (Fluoromethyl) benzene was used as the model target compound. Precursors containing perfluoroalkyl and perfluoroaryl sulfonate moieties were subjected to nucleophilic F-18-fluorination, and the impact of perfluoro groups on the substitution reaction and product purification was investigated. [F-18]Fluoride interacted with perfluoroalkyl chains, precluding nucleophilic substitution. When perfluoroaryl groups were used, the substitution proceeded, and the separation of product was explored. The radiolabelled product was obtained in 32% analytical yield and the radiochemical purity was increased to approximately 77% using fluorous solid phase extraction purification.
Place, publisher, year, edition, pages
2010. Vol. 53, no 1, 24-30 p.
perfluoro, nucleophilic 18F-fluorination, F-SPE, chemical reactivity, purification
IdentifiersURN: urn:nbn:se:uu:diva-108587DOI: 10.1002/jlcr.1695ISI: 000275388100005OAI: oai:DiVA.org:uu-108587DiVA: diva2:249183