Synthesis of 18F-labeled biotin analogues
2011 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 54, no 10, 681-683 p.Article in journal (Refereed) Published
A one-step 18F-labeling strategy was used to prepare three labeled analogues of the vitamin biotin, which can be a useful tracer because of its high affinity for avidin. The labeled compounds were obtained in decay-corrected yields of up to 35%, and specific radioactivity of 320 ± 60 GBq/mmol. When evaluated in situ, the analogues showed good affinity for avidin: 60–75% of the radiolabeled compounds were bound to avidin within 5 min. The binding was site-specific, as shown by blocking experiments with native biotin.
Place, publisher, year, edition, pages
2011. Vol. 54, no 10, 681-683 p.
IdentifiersURN: urn:nbn:se:uu:diva-108584DOI: 10.1002/jlcr.1913ISI: 000295901500017OAI: oai:DiVA.org:uu-108584DiVA: diva2:271581