Thermoresponsive, Hydrolytically Degradable Polymer Micelles Intended for Radionuclide Delivery
2009 (English)In: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 9, no 10, 1016-1027 p.Article in journal (Refereed) Published
Novel polymer micelles, prepared by self-assembling thermoresponsive poly(N-isopropylacrylamide)-graft-poly[N-(2-hydroxypropyl)methacrylamide] copolymers with hydrolytically degradable N-glycosylamine groups between the polymer blocks are proposed for delivery of diagnostic and therapeutic radionuclides into solid tumors. The micelles are formed by fast heating of an aqueous solution of the copolymer to 37 °C. They have a hydrodynamic diameter of 128 nm (measured using dynamic light scattering) and slowly degrade during incubation in aqueous buffer at pH = 7.4. Labeling with both 131I and 90Y proceeds with high yields (>85%). The unlabeled polymers are not cytotoxic for any of the tested murine and human cell lines.
Place, publisher, year, edition, pages
2009. Vol. 9, no 10, 1016-1027 p.
drug-delivery systems, micelles, radioisotopes, thermoresponsive polymers
Research subject Physical Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-109259DOI: 10.1002/mabi.200900083ISI: 000271174100009PubMedID: 19554646OAI: oai:DiVA.org:uu-109259DiVA: diva2:271731