Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma
2009 (English)In: Oncogene, ISSN 0950-9232, E-ISSN 1476-5594, Vol. 28, no 23, 2266-2275 p.Article in journal (Refereed) Published
Gliomas are primary brain tumors mainly affecting adults. The cellular origin is unknown. The recent identification of tumor-initiating cells in glioma, which share many similarities with normal neural stem cells, has suggested the cell of origin to be a transformed neural stem cell. In previous studies, using the RCAS/tv-a mouse model, platelet-derived growth factor B (PDGF-B)-induced gliomas have been generated from nestin or glial fibrillary acidic protein-expressing cells, markers of neural stem cells. To investigate if committed glial progenitor cells could be the cell of origin for glioma, we generated the Ctv-a mouse where tumor induction would be restricted to myelinating oligodendrocyte progenitor cells (OPCs) expressing 2',3'-cyclic nucleotide 3'-phosphodiesterase. We showed that PDGF-B transfer to OPCs could induce gliomas with an incidence of 33%. The majority of tumors resembled human WHO grade II oligodendroglioma based on close similarities in histopathology and expression of cellular markers. Thus, with the Ctv-a mouse we have showed that the cell of origin for glioma may be a committed glial progenitor cell.
Place, publisher, year, edition, pages
2009. Vol. 28, no 23, 2266-2275 p.
glioma, cell of origin, neural stem cell, oligodendrocyte progenitor cell, glial cell, PDGF
Medical and Health Sciences
Research subject Molecular Medicine
IdentifiersURN: urn:nbn:se:uu:diva-109379DOI: 10.1038/onc.2009.76ISI: 000266886300003PubMedID: 19421151OAI: oai:DiVA.org:uu-109379DiVA: diva2:272190