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Insulin-like growth factor binding protein-1 is a long-term predictor of heart failure in survivors of a first acute myocardial infarction and population controls
Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
2010 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 138, no 1, 50-55 p.Article in journal (Refereed) Published
Abstract [en]


Only a few studies have investigated the prospective relationship between insulin-like growth factor binding protein-1 (IGFBP-1) and cardiovascular events and the results are conflicting.


In this prospective cohort study, we followed both cases, i.e. survivors of a first acute myocardial infarction (AMI) and their age, sex and hospital catchment area matched controls of a large population-based case-control study for 8 years for total and cardiac mortality, AMI, stroke and hospitalization for heart failure (HF). Levels of IGFBP-1 were measured three months after AMI in a stable metabolic phase in 853 patients. For 1106 control subjects, the time of measurement was as close as possible to that of 'his/her' case. Established cardiovascular risk and prognostic factors were also determined.


Higher IGFBP-1 values predicted hospitalization for HF during follow-up both in the patient and the control cohort. Control subjects with higher IGFBP-1 values had elevated mortality when compared to those with the lowest quartile. The associations between IGFBP-1 and other outcomes investigated in this study, i.e. mortality among patients, AMI or stroke among patients and controls were weak and statistically not significant.


Levels of IGFBP-1 consistently predicted HF both among survivors of a first AMI and their matched controls. Our results suggest that IGFBP-1 levels might also predict mortality in a population free of previous AMI.

Place, publisher, year, edition, pages
2010. Vol. 138, no 1, 50-55 p.
Keyword [en]
IGFBP-1, Heart failure, Acute myocardial infarction, Prognosis
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-109677DOI: 10.1016/j.ijcard.2008.08.003ISI: 000272354500015PubMedID: 18793810OAI: oai:DiVA.org:uu-109677DiVA: diva2:273446
Available from: 2009-10-21 Created: 2009-10-21 Last updated: 2012-07-25Bibliographically approved

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