Repeated l-DOPA treatment increases c-fos and BDNF mRNAs in the subthalamic nucleus in the 6-OHDA rat model of Parkinson's disease
2006 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 1095, 207-210 p.Article in journal (Refereed) Published
The subthalamic nucleus and the striatum are input regions of the basal ganglia. This study used the unilateral 6-OHDA rat model of Parkinson's disease to examine effects of l-DOPA on the expression of c-fos and BDNF mRNAs in these nuclei. Dopamine depletion per se did not affect c-fos or BDNF. Both a single and repeated injections of l-DOPA induced c-fos, but not BDNF, in the dopamine-depleted striatum. However, repeated l-DOPA treatment increased c-fos and BDNF in the dopamine-depleted subthalamic nucleus. These molecular adaptations may reflect changes in neuronal plasticity that underlie some therapeutic actions and/or side effects of l-DOPA in Parkinson's disease.
Place, publisher, year, edition, pages
2006. Vol. 1095, 207-210 p.
basal ganglia; BDNF; immediate early gene; movement disorder
Medical and Health Sciences Pharmaceutical Sciences
IdentifiersURN: urn:nbn:se:uu:diva-109746DOI: 10.1016/j.brainres.2006.04.019ISI: 000238863700024PubMedID: 16725125OAI: oai:DiVA.org:uu-109746DiVA: diva2:273921