uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Repeated l-DOPA treatment increases c-fos and BDNF mRNAs in the subthalamic nucleus in the 6-OHDA rat model of Parkinson's disease
Karolinska Institutet, Institutionen för fysiologi och farmakologi . (Translationell neurofarmakologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences, MMS, Medical Mass Spectrometry.
Karolinska Institutet, Institutionen för fysiologi och farmakologi. (Translationell neurofarmakologi)
2006 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 1095, 207-210 p.Article in journal (Refereed) Published
Abstract [en]

The subthalamic nucleus and the striatum are input regions of the basal ganglia. This study used the unilateral 6-OHDA rat model of Parkinson's disease to examine effects of l-DOPA on the expression of c-fos and BDNF mRNAs in these nuclei. Dopamine depletion per se did not affect c-fos or BDNF. Both a single and repeated injections of l-DOPA induced c-fos, but not BDNF, in the dopamine-depleted striatum. However, repeated l-DOPA treatment increased c-fos and BDNF in the dopamine-depleted subthalamic nucleus. These molecular adaptations may reflect changes in neuronal plasticity that underlie some therapeutic actions and/or side effects of l-DOPA in Parkinson's disease.

Place, publisher, year, edition, pages
2006. Vol. 1095, 207-210 p.
Keyword [en]
basal ganglia; BDNF; immediate early gene; movement disorder
National Category
Medical and Health Sciences Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-109746DOI: 10.1016/j.brainres.2006.04.019ISI: 000238863700024PubMedID: 16725125OAI: oai:DiVA.org:uu-109746DiVA: diva2:273921
Available from: 2009-10-26 Created: 2009-10-23 Last updated: 2016-08-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Andrén, Per E.
By organisation
MMS, Medical Mass Spectrometry
In the same journal
Brain Research
Medical and Health SciencesPharmaceutical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 182 hits
ReferencesLink to record
Permanent link

Direct link