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The Miro GTPases: at the heart of the mitochondrial transport machinery
Department of Microbiology, Tumour and Cell Biology, Karolinska Institute, Box 280, SE-171 77 Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Department of Microbiology, Tumour and Cell Biology, Karolinska Institute, Box 280, SE-171 77 Stockholm, Sweden.
2009 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 583, no 9, 1391-1398 p.Article, review/survey (Refereed) Published
Abstract [en]

Mitochondria are organelles of elaborate structure that in addition to supplying cellular energy, have significant roles in calcium homeostasis and apoptosis. Failure to maintain mitochondrial dynamics results in neurodegenerative diseases and neuromuscular pathologies. The Miro GTPases, which constitute a unique subgroup of the Ras superfamily, have emerged as essential regulators of mitochondrial morphogenesis and trafficking along microtubules. Miro GTPases function as calcium-dependent sensors in the control of mitochondrial motility. Increased awareness of the biological function of Miro GTPases can contribute to elucidate the molecular mechanisms underlying diseases caused by deregulated mitochondrial dynamics.

Place, publisher, year, edition, pages
Elsevier B.V. on behalf of the Federation of European Biochemical Societies , 2009. Vol. 583, no 9, 1391-1398 p.
Keyword [en]
Miro, GTPase, Milton, Mitochondrion, Microtubule
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-109838DOI: 10.1016/j.febslet.2009.04.015ISI: 000266402400001PubMedID: 19376118OAI: oai:DiVA.org:uu-109838DiVA: diva2:274141
Available from: 2009-10-27 Created: 2009-10-27 Last updated: 2017-12-12Bibliographically approved

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