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Maltreatment, MAOA, and delinquency: Sex differences in gene-environment interaction in a large population-based cohort of adolescents
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland.
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2011 (English)In: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 41, no 2, 262-272 p.Article in journal (Refereed) Published
Abstract [en]

The present study investigated a possible interaction between a functional polymorphism in the MAOA gene promoter (MAOA-VNTR) and childhood maltreatment in the prediction of adolescent male and female delinquency. A cohort of 1 825 high school students, 17-18 years old, completed an anonymous questionnaire during class hours which included questions on childhood maltreatment, sexual abuse, and delinquency. Saliva samples were collected for DNA isolation, and analyzed for the MAOA-VNTR polymorphism.

Self-reported maltreatment was a strong risk factor for adolescent delinquent behavior. The MAOA genotype also showed a significant main effect when controlled for maltreatment. Boys with a short variant and girls with one or two long variants of the polymorphism showed a higher risk for delinquency when exposed to maltreatment. Our results confirm previous findings of an interaction between the MAOA-VNTR polymorphism and self-reported maltreatment. Results for boys and girls differ according to MAOA-VNTR genotype and direction of phenotypic expression.

Place, publisher, year, edition, pages
2011. Vol. 41, no 2, 262-272 p.
Keyword [en]
Monoamine oxidase, child maltreatment, juvenile delinquency, sex characteristics, MAOA, gene-environment interaction
National Category
Psychiatry
Research subject
Child and Youth Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-109848DOI: 10.1007/s10519-010-9356-yISI: 000287749700010PubMedID: 20734127OAI: oai:DiVA.org:uu-109848DiVA: diva2:274230
Available from: 2009-10-27 Created: 2009-10-27 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Depression and Antisocial Behaviour in Adolescents: Influence of Social Status, Shaming, and Gene-Environment Interaction
Open this publication in new window or tab >>Depression and Antisocial Behaviour in Adolescents: Influence of Social Status, Shaming, and Gene-Environment Interaction
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis investigated (1) social status and shaming experiences in relation to aggressive behaviour and depression, and (2) gene-environment interactions between two genetic polymorphisms related to the serotonergic system – MAOA-VNTR and 5HTTLPR – and experiences of maltreatment in relation to delinquent behaviour and depression among adolescents.

The four included studies are based on questionnaire data from the Survey of Adolescent Life in Vestmanland 2006 (SALVe-2006). A total of 5396 students in 9th (15-16 years old) grade of elementary school and 2nd (17-18 years old) grade of high school comprised the target population. The students in 2nd grade of high school also provided a saliva sample for gene extraction.

There were strong associations between shaming experiences and both aggressive behaviour and depression. In addition, individuals who reported many shaming experiences and had either low or high social status had increased risks of physical aggression or depression, whereas medium social status seemed to have a protective effect.

Gene-environment interactions were found between experiences of maltreatment and the MAOA-VNTR in relation to delinquent behaviour. Moreover, the direction of the gene-environment interaction differed depending on sex: boys with the short (S) variant of the MAOA-VNTR, in contrast to girls with the long (LL) variant, had the highest risk of delinquency in combination with maltreatment.

Gene-environment interactions were also found between experiences of maltreatment and the 5HTTLPR in relation to depression among girls. The girls that were homozygous for the S allele (SS) had the highest risk of depression in combination with maltreatment. Among boys however, no gene-environment interaction was found between the 5HTTLPR and maltreatment in relation to depression.

In conclusion, it is important to consider both genetic effects, and psychosocial factors such as social status, shaming experiences, and experiences of maltreatment when investigating different aspects of health and behaviour among adolescents.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2009. 100 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 494
Keyword
adolescent, antisocial behaviour, depression, gene-environment interaction, maltreatment, monoamine oxidase, serotonin, shame, social status
National Category
Psychiatry
Research subject
Child and Youth Psychiatry
Identifiers
urn:nbn:se:uu:diva-109851 (URN)978-91-554-7649-6 (ISBN)
Public defence
2009-12-10, Samlingssalen Psykiatricentrum, Ing 29, Centrallasarettet, Västerås, 13:15 (Swedish)
Opponent
Supervisors
Available from: 2009-12-01 Created: 2009-10-27 Last updated: 2009-12-01Bibliographically approved

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