Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells
2010 (English)In: Journal of Comparative Neurology, ISSN 0021-9967, E-ISSN 1096-9861, Vol. 518, no 12, 2284-2304 p.Article in journal (Refereed) Published
Spinal cholinergic neurons are critical for motor function in both the autonomic and somatic nervous systems and are affected in spinal cord injury and in diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy. Using two screening approaches and in situ hybridization, we identified 159 genes expressed in typical cholinergic patterns in the spinal cord. These include two general cholinergic neuron markers, one gene exclusively expressed in motor neurons and nine genes expressed in unknown subtypes of somatic motor neurons. Further, we present evidence that Chondrolectin (Chodl) is a novel genetic marker for putative fast motor neurons and that estrogen-related receptor b (ERRb) is a candidate genetic marker for slow motor neurons. In addition, we suggest paired-like homeodomain transcription factor 2 (Pitx2) as a marker for cholinergic partition cells.
Place, publisher, year, edition, pages
2010. Vol. 518, no 12, 2284-2304 p.
mouse genetics, neuronal network, interneuron, motor neuron, spinal cord, genetic screen
Medical and Health Sciences
Research subject Developmental Neurosciences; Genetics
IdentifiersURN: urn:nbn:se:uu:diva-109916DOI: 10.1002/cne.22332ISI: 000277580600007PubMedID: 20437528OAI: oai:DiVA.org:uu-109916DiVA: diva2:274579