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Automated pre-ejection period variation predicts fluid responsiveness in low tidal volume ventilated pigs
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2010 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 54, no 2, 199-205 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: The respiratory variation in the pre-ejection period (DeltaPEP) has been used to predict fluid responsiveness in mechanically ventilated patients. Recently, we automated this parameter and indexed it to tidal volume (PEPV) and showed that it was a reliable predictor for post-cardiac surgery, mainly paced, patients ventilated with low tidal volumes. The aims of the present animal study were to investigate PEPV's ability to predict fluid responsiveness under different fluid loading conditions and natural heart rates during low tidal volume ventilation (6 ml/kg) and to compare the performance of PEPV with other markers of fluid responsiveness. Methods: Eight prone, anesthetized piglets (23-27 kg) ventilated with tidal volumes of 6 ml/kg were subjected to a sequence of 25% hypovolemia, normovolemia, and 25% and 50% hypervolemia. PEPV, DeltaPEP, pulse pressure variation (PPV), central venous pressure (CVP), and pulmonary artery occlusion pressure (PAOP) were measured before each volume expansion. Results: Sensitivity was 89% and specificity was 93% for PEPV, 78% and 93% for DeltaPEP, 89% and 100% for PPV, 78% and 93% for CVP, and 89% and 87% for PAOP. Conclusion: PEPV predicts fluid responsiveness in low tidal volume ventilated piglets.

Place, publisher, year, edition, pages
2010. Vol. 54, no 2, 199-205 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-109925DOI: 10.1111/j.1399-6576.2009.02061.xISI: 000273448700012PubMedID: 19681786OAI: oai:DiVA.org:uu-109925DiVA: diva2:274665
Available from: 2009-10-30 Created: 2009-10-30 Last updated: 2010-12-20Bibliographically approved

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