uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Should dynamic parameters for prediction of fluid responsiveness be indexed to the tidal volume?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2010 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 54, no 2, 191-198 p.Article in journal (Refereed) Published
Abstract [en]

Background: The respiratory variation in the pre-ejection period (DeltaPEP) has been used to predict fluid responsiveness in mechanically ventilated patients. Recently, we modified this parameter (PEPV) and showed that it was a reliable predictor for post-cardiac surgery, mainly paced, patients when moderately low tidal volumes were used. One of the modifications involved tidal volume indexation, which had not been proposed before for dynamic parameters. The aim of the present animal study was to investigate whether indexation to tidal volume should be part of a new definition of dynamic parameters such as the case for our newly proposed PEPV. Methods: Eight prone, anesthetized piglets (23-27 kg) were subjected to a sequence of 25% hypovolemia, normovolemia, and 25% and 50% hypervolemia. At each volemic level, tidal volumes were varied in three steps: 6, 9, and 12 ml/kg. PEP variations (ms) and pulse-pressure variation (PPV) were measured during the three tidal volume steps at each volemic level. Results: PEP variations increased significantly with increasing tidal volume at all volemic levels but 50% hypervolemia and were proportionally related to the tidal volume at normovolemia. PPV increased significantly with increasing tidal volume at all volemic levels and was roughly proportional to the tidal volume at all volemic levels but hypovolemia. Conclusion: Our study indicates that dynamic parameters are improved by indexing to tidal volume.

Place, publisher, year, edition, pages
2010. Vol. 54, no 2, 191-198 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-109926DOI: 10.1111/j.1399-6576.2009.02114.xISI: 000273448700011PubMedID: 19764908OAI: oai:DiVA.org:uu-109926DiVA: diva2:274667
Available from: 2009-10-30 Created: 2009-10-30 Last updated: 2010-12-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Anaesthesiology and Intensive Care
In the same journal
Acta Anaesthesiologica Scandinavica
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 161 hits
ReferencesLink to record
Permanent link

Direct link