uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The effect of activating and inhibiting Fc-receptors on murine mercury-induced autoimmunity.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2008 (English)In: Journal of Autoimmunity, ISSN 0896-8411, Vol. 31, no 1, 22-29 p.Article in journal (Refereed) Published
Abstract [en]

Fc-receptors for IgG (Fc gamma R) link cellular and humoral immune responses, controlling the balance between activating and inhibitory immune responses, and are involved in autoimmune diseases. Mercury (Hg) induces an autoimmune condition in genetically (H-2(s,q,f)) susceptible mice characterized by lymphoproliferation, hypergammaglobulinemia and IgG antinucleolar antibodies (ANoA). Here we investigate the role of activating (Fc gamma RI, Fc gamma RIII) and inhibitory (Fc gamma RIIb) Fc-receptors on mercury-induced autoimmunity (HgIA) using DBA/1 mice (H-2(q))(-) with targeted Fc gamma R mutations and wild type (wt) mice. Mice deficient for the FcR gamma-chain or FcyRIII and treated with 15 mg/L HgCl2 showed a delayed and attenuated IgG1, IgG2a and IgG2b ANoA response compared to wt mice. Female Hg-treated FcyRIIB(-/-) mice showed a significant increased of lgG2b ANoA development compared to wt mice. The total serum IgG1 response due to Hg was attenuated in FcR gamma(-/-) and Fe gamma RIII-/- mice compared to wt mice. Hg-treated Fc gamma RIIB-/- mice showed an increase of both serum IgG1 and IgE compared to wt mice. We conclude that FcyRIII is of importance for the rapidity and final strength of the ANoA response and the increase in serum IgG1 in HgIA, while lack of Fc gamma RIIb increases the IgG2b ANoA response and the serum IgG1 and IgE response.

Place, publisher, year, edition, pages
2008. Vol. 31, no 1, 22-29 p.
Keyword [en]
Mercury, Fc gamma R, autoimmunity, mice, ANoA
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-110005DOI: 10.1016/j.jaut.2008.01.002ISI: 000257243300004PubMedID: 18314309OAI: oai:DiVA.org:uu-110005DiVA: diva2:275005
Available from: 2009-11-02 Created: 2009-11-02 Last updated: 2009-11-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Cell and Molecular Biology
In the same journal
Journal of Autoimmunity
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 261 hits
ReferencesLink to record
Permanent link

Direct link