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Synthesis of C-11-labelled metomidate analogues as adrenocortical imaging agents.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
2008 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 51, no 6, p. 273-276Article in journal (Refereed) Published
Abstract [en]

Clinical findings using [C-11]methyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate ([C-11]MTO, 1) show high uptake in lesions of adrenocortical origin, including adenomas, but low uptake in lesions of non-adrenocortical origin. In this paper the synthesis and preclinical evaluation of two new C-11-labelled analogues of MTO, [C-11]methyl 1-[(1R)-1-(4-chlorophenyl)ethyl]-1H-imidazole-5-carboxylate ([C-11]CLM, 2) and [C-11]methyl 1-[(1R)-1-(4-bromophenyl)ethyl]-1H-imidazole-5-carboxylate ([C-11]BRM, 3), using frozen-section autoradiography, organ distribution and a metabolic study are presented.

Place, publisher, year, edition, pages
2008. Vol. 51, no 6, p. 273-276
Keywords [en]
PET, [C-11]methylation, MTO, metomidate, adrenocortical tumours
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-110018DOI: 10.1002/jlcr.1517ISI: 000257341900031OAI: oai:DiVA.org:uu-110018DiVA, id: diva2:275022
Available from: 2009-11-02 Created: 2009-11-02 Last updated: 2017-12-12Bibliographically approved

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