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Differences in expression of tumor markers between pre- and postmenopausal women with invasive cervical cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
2008 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 28, no 3B, 1793-1795 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to investigate the differences in the expression of tumor markers in squamous cell and in adenomatous carcinomas in pre- and postmenopausal women, respectively. Patients and Methods: The study population comprised 53 premenopausal and 107 postmenopausal women. Thirty-four tumors were adenomatous (n=31) or adenosquamous carcinomas (n=3), distributed between 13 premenopausal and 21 postmenopausal women. The remaining 126 squamous cell carcinomas were diagnosed in 40 pre- and 86 postmenopausal women. Expression of ten tumor markers of possible clinical importance in cervical cancer was evaluated. Results: Expression of three tumor markers, p53 (> ;0% vs. 0%), p27 (> , 20% vs. < ;20%) and cyclooxygenase-2 (COX-2) (high intensity vs. moderate/none) differed significantly between pre- compared to postmenopausal women with squamous cell (p27, 54% vs. 72%, p=0.009) or adenomatous carcinomas (p53, 8% vs. 63%, p=0.006 and COX-2, 46% vs. 20%, p=0.03). All results were adjusted for clinical cancer stage. Conclusion: The unusual age-specific incidence curve in cervical cancer has rarely been related to expression of tumor markers. Age-related differences in expression of tumor markers could reflect some age-related different biological mechanisms in cervical cancer.

Place, publisher, year, edition, pages
2008. Vol. 28, no 3B, 1793-1795 p.
Keyword [en]
cervical cancer, markers, p53, p27, COX-2, Ki-67, EGFR, E-cadherin, c-myc, VEGF, CD44, CD4, age-specific expression
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-110049ISI: 000256940700012PubMedID: 18630462OAI: oai:DiVA.org:uu-110049DiVA: diva2:275071
Available from: 2009-11-03 Created: 2009-11-02 Last updated: 2010-07-19Bibliographically approved

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