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Fc gamma RI-Mediated activation of human mast cells promotes survival and induction of the pro-survival gene bfl-1
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
2008 (English)In: Journal of Clinical Immunology, ISSN 0271-9142, E-ISSN 1573-2592, Vol. 28, no 3, 250-255 p.Article in journal (Refereed) Published
Abstract [en]

Activation of mast cells through either Fc epsilon RI or Fc gamma RI leads to release of mediators contributing to the inflammatory response. One of the biologic characteristics of mast cells in allergic pathology is that these cells have the capacity to recover and regranulate after aggregation of Fc epsilon RI. We have previously demonstrated that the prosurvival protein A1/Bfl-1 is required for mast cells to survive IgE-mediated activation. In the present study, we have investigated whether human mast cells show similar induction of bfl-1 and activation-induced survival after aggregation of Fc gamma RI. Human cord blood-derived mast cells were activated by aggregation of either Fc epsilon RI or Fc gamma RI, and activation-induced survival and induction of bfl-1 was measured. We found that aggregation of Fc gamma RI-induced expression of bf-1 and caused a comparable activation-induced mast cell survival as Fc epsilon RI does. These data suggests that activation through Fc-receptors contribute to mast cell survival during antibody-dependent mast cell mediated inflammatory responses.

Place, publisher, year, edition, pages
2008. Vol. 28, no 3, 250-255 p.
Keyword [en]
bfl-1, Fc epsilon RI, Fc gamma RI, mast cell, survival
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-110188DOI: 10.1007/s10875-007-9153-4ISI: 000255956500007PubMedID: 18071883OAI: oai:DiVA.org:uu-110188DiVA: diva2:275516
Available from: 2009-11-05 Created: 2009-11-05 Last updated: 2017-12-12Bibliographically approved

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