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Subattomole sensitivity in biological accelerator mass spectrometry
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Ion Physics. (jonfysik)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Ion Physics. (jonfysik)
2008 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 80, no 10, 3515-3521 p.Article in journal (Refereed) Published
Abstract [en]

The Uppsala University 5 MV Pelletron tandem accelerator has been used to study C-14-labeled biological samples utilizing accelerator mass spectrometry (ANIS) technology. We have adapted a sample preparation method for small biological samples down to a few tens of micrograms of carbon, involving among others, miniaturizing of the graphitization reactor. Standard AMS requires about 1 mg of carbon with a limit of quantitation of about 10 amol. Results are presented for a range of small sample sizes with concentrations down to below 1 pM of a pharmaceutical substance in human blood. It is shown that C-14-labeled molecular markers can be routinely measured from the femtomole range down to a few hundred zepto-mole (10(-21) mol), without the use of any additional separation methods.

Place, publisher, year, edition, pages
2008. Vol. 80, no 10, 3515-3521 p.
National Category
Subatomic Physics Engineering and Technology
Research subject
Ion Physics
Identifiers
URN: urn:nbn:se:uu:diva-110208DOI: 10.1021/ac800174jISI: 000255871500001OAI: oai:DiVA.org:uu-110208DiVA: diva2:275546
Available from: 2009-11-05 Created: 2009-11-05 Last updated: 2017-12-12

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Salehpour, MehranPossnert, Göran

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