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Xylose as a carrier for boron containing compounds
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
2008 (English)In: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1464-3405, Vol. 18, no 7, 2451-2454 p.Article in journal (Refereed) Published
Abstract [en]

A xylosylated carborane was synthesized by standard carbohydrate methodology and tested on normal HFL-1 cells as well as transformed T24 cells. The xylosylated carborane initiated glycosaminoglycan (GAG) synthesis in both cell lines and treatment with the carborane gave a pronounced translocation of proteoglycans to the nuclei of T24 cells. However, most of the boron-containing compounds were secreted to the medium. We conclude that xylosides carrying carboranes are not suitable for boron neutron capture therapy (BNCT) for T24 cells. However, the uptake of boron-containing xyloside, the GAG priming capacity, and the nuclear translocation of glypican-1 make this xyloside a candidate for further investigation for selectivity toward other tumor cell lines.

Place, publisher, year, edition, pages
2008. Vol. 18, no 7, 2451-2454 p.
Keyword [en]
boron neutron capture therapy, carborane, xyloside, glycosaminoglycan
National Category
Chemical Sciences
URN: urn:nbn:se:uu:diva-110419DOI: 10.1016/j.bmcl.2008.02.048ISI: 000255246300042PubMedID: 18325767OAI: oai:DiVA.org:uu-110419DiVA: diva2:277196
Available from: 2009-11-16 Created: 2009-11-16 Last updated: 2010-10-19Bibliographically approved

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