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Kinetics of asthma- and allergy-associated immune response gene expression in peripheral blood mononuclear cells from vaccinated infants after in vitro re-stimulation with vaccine antigen
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2008 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 26, no 14, 1725-1730 p.Article in journal (Refereed) Published
Abstract [en]

The global expression of immune response genes in infants after vaccination and their role in asthma and allergy is not clearly understood. Pharmacogenomics is ideally suited to study the involved cellular responses, since the expression of thousands of genes can be assessed simultaneously. Here, array technology was used to assess the expression kinetics of immune response genes with association to asthma and allergy in peripheral blood mononuclear cells (PBMC) of five healthy infants after vaccination with Infanrix-Polio + Hib. At 12 h after in vitro re-stimulation of the PBMC with pertussis toxin (PT) antigen, 14 immune response pathways, 33 allergy-related and 66 asthma-related genes were found activated.

Place, publisher, year, edition, pages
2008. Vol. 26, no 14, 1725-1730 p.
Keyword [en]
pharmacogenomics, asthma, allergy
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-110444DOI: 10.1016/j.vaccine.2008.01.041ISI: 000254655100002PubMedID: 18336961OAI: oai:DiVA.org:uu-110444DiVA: diva2:277203
Available from: 2009-11-16 Created: 2009-11-16 Last updated: 2010-10-26Bibliographically approved

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