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Transcriptome Profiling of Human Pre-Implantation Development
Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden.
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2009 (English)In: PloS one, ISSN 1932-6203, Vol. 4, no 11, e7844- p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Preimplantation development is a crucial step in early human development. However, the molecular basis of human preimplantation development is not well known. METHODOLOGY: By applying microarray on 397 human oocytes and embryos at six developmental stages, we studied the transcription dynamics during human preimplantation development. PRINCIPAL FINDINGS: WE FOUND THAT THE PREIMPLANTATION DEVELOPMENT CONSISTED OF TWO MAIN TRANSITIONS: from metaphase-II oocyte to 4-cell embryo where mainly the maternal genes were expressed, and from 8-cell embryo to blastocyst with down-regulation of the maternal genes and up-regulation of embryonic genes. Human preimplantation development proved relatively autonomous. Genes predominantly expressed in oocytes and embryos are well conserved during evolution. SIGNIFICANCE: Our database and findings provide fundamental resources for understanding the genetic network controlling early human development.

Place, publisher, year, edition, pages
2009. Vol. 4, no 11, e7844- p.
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-110741DOI: 10.1371/journal.pone.0007844PubMedID: 19924284OAI: oai:DiVA.org:uu-110741DiVA: diva2:278149
Available from: 2009-11-24 Created: 2009-11-24 Last updated: 2010-07-20Bibliographically approved

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