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Assessment of intravascular volume by transthoracic echocardiography during therapeutic hypothermia and rewarming in cardiac arrest survivors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2009 (English)In: Resuscitation, ISSN 0300-9572, E-ISSN 1873-1570, Vol. 80, no 11, 1234-1239 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To study haemodynamic effects and changes in intravascular volume during hypothermia treatment, induced by ice-cold fluids and maintained by ice-packs followed by rewarming in patients after resuscitation from cardiac arrest. MATERIALS AND METHODS: In 24 patients following successful restoration of spontaneous circulation (ROSC), hypothermia was induced with infusion of 4 degrees C normal saline and maintained with ice-packs for 26 h after ROSC. This was followed by passive rewarming. Transthoracic echocardiography was performed at 12, 24 and 48 h after ROSC to evaluate ejection fraction and intravascular volume status. Central venous pressure (CVP), central venous oxygen saturation (ScvO(2)) and serum lactate were measured. Fluid balance was calculated. RESULTS: Twelve hours after ROSC, two separate raters independently estimated that 10 and 13 out of 23 patients had a decreased intravascular volume using transthoracic echocardiography. After 24 and 48 h this number had increased further to 14 and 13 out of 19 patients and 13 and 12 out of 21 patients. Calculated fluid balance was positive (4000 ml the day 1 and 2500 ml day 2). There was no difference in ejection fraction between the recording time points. Serum lactate and ScvO(2) were in the normal range when echocardiography exams were performed. CVP did not alter over time. CONCLUSIONS: Our results support the hypothesis that inducing hypothermia following cardiac arrest, using cold intravenous fluid infusion does not cause serious haemodynamic side effects. Serial transthoracic echocardiographic estimation of intravascular volume suggests that many patients are hypovolaemic during therapeutic hypothermia and rewarming in spite of a positive fluid balance.

Place, publisher, year, edition, pages
2009. Vol. 80, no 11, 1234-1239 p.
Keyword [en]
Cardiac arrest, Cardiopulmonary resuscitation, Hypothermia, Haemodynamics, Echocardiography, Intensive care
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-110823DOI: 10.1016/j.resuscitation.2009.06.035ISI: 000272009600005PubMedID: 19716641OAI: oai:DiVA.org:uu-110823DiVA: diva2:278459
Available from: 2009-11-26 Created: 2009-11-26 Last updated: 2017-12-12Bibliographically approved

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Johansson, JakobCovaciu, LucianMörtberg, ErikRubertsson, Sten

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Anaesthesiology and Intensive CareDepartment of Medical Sciences
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