uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Perinatal exposure to PCB 153, but not PCB 126, alters bone tissue composition in female goat offspring
Show others and affiliations
2006 (English)In: Toxicology, ISSN 0300-483X, E-ISSN 1879-3185, Vol. 228, no 1, 33-40 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate if environmentally relevant doses of the putative estrogenic non dioxin-like PCB 153 and the dioxin-like PCB 126 caused changes in bone tissue in female goat offspring following perinatal exposure. Goat dams were orally dosed with PCB 153 in corn oil (98 microg/kg body wt/day) or PCB 126 (49 ng/kg body wt/day) from day 60 of gestation until delivery. The offspring were exposed to PCB in utero and through mother's milk. The suckling period lasted for 6 weeks. Offspring metacarpal bones were analysed using peripheral quantitative computed tomography (pQCT) after euthanisation at 9 months of age. The diaphyseal bone was analysed at a distance of 18% and 50% of the total bone length, and the metaphyseal bone at a distance of 9%. Also, biomechanical three-point bending of the bones was conducted, with the load being applied to the mid-diaphyseal pQCT measure point (50%). PCB 153 exposure significantly decreased the total cross-sectional area (125 mm(2)+/-4) versus non-exposed (142 mm(2)+/-5), decreased the marrow cavity (38 mm(2)+/-4) versus non-exposed (50 mm(2)+/-3) and decreased the moment of resistance (318 mm(3)+/-10) versus non-exposed (371 mm(3)+/-20) at the diaphyseal 18% measure point. At the metaphyseal measure point, the trabecular bone mineral density (121 mg/cm(3)+/-5) was increased versus non-exposed (111 mg/cm(3)+/-3). PCB 126 exposure did not produce any observable changes in bone tissue. The biomechanical testing of the bones did not show any significant changes in bone strength after PCB 153 or PCB 126 exposure. In conclusion, perinatal exposure to PCB 153, but not PCB 126, resulted in altered bone composition in female goat offspring.

Place, publisher, year, edition, pages
2006. Vol. 228, no 1, 33-40 p.
Keyword [en]
2, 2′, 4, 4′, 5, 5′-Hexachlorobiphenyl (PCB 153); 3, 3′, 4, 4′, 5-Pentachlorobiphenyl (PCB 126), Biomechanics, Development, Peripheral quantitative computed tomography, Trabecular
National Category
Medical and Health Sciences
Research subject
URN: urn:nbn:se:uu:diva-111760DOI: 10.1016/j.tox.2006.08.016ISI: 000242135900004PubMedID: 17007988OAI: oai:DiVA.org:uu-111760DiVA: diva2:282669
Available from: 2009-12-21 Created: 2009-12-21 Last updated: 2012-03-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Larsson, SuneÖrberg, JanLind, Monica
By organisation
Environmental ToxicologyOrthopaedics
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 234 hits
ReferencesLink to record
Permanent link

Direct link