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Can we improve fixation and outcomes?: Use of bone substitutes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
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2009 (English)In: Journal of Orthopaedic Trauma, ISSN 0890-5339, E-ISSN 1531-2291, Vol. 23, no 6, 422-425 p.Article in journal (Refereed) Published
Abstract [en]

Hip fractures secondary to osteoporosis are common in the elderly. Stabilizing these fractures until union is achieved is a challenge due to poor bone stock and insufficient purchase of the implant to the bone. The reported high rate of complications has prompted extensive research in the development of fixation techniques. Furthermore, manipulation of both the local fracture environment in terms of application of growth factors, scaffolds, and mesenchymal cells and the systemic administration of agents promoting bone formation and bone strength has been considered as a treatment option with promising results. There are only a few evidence-based studies reporting on fixation augmentation techniques. This article reports on the efficacy of bone graft substitutes for the fixation of hip fractures, in particular calcium phosphates, which have been used as granules, cements, and implant coatings.

Place, publisher, year, edition, pages
2009. Vol. 23, no 6, 422-425 p.
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URN: urn:nbn:se:uu:diva-111765DOI: 10.1097/BOT.0b013e3181771426ISI: 000267499500007PubMedID: 19550228OAI: oai:DiVA.org:uu-111765DiVA: diva2:282681
Available from: 2009-12-21 Created: 2009-12-21 Last updated: 2011-04-28Bibliographically approved

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