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Evidence-based use of medications in patients with coronary artery disease in a rural Australian community
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences, Division of Pharmacokinetics and Drug Therapy.
2007 (English)In: The Australian journal of rural health, ISSN 1038-5282, E-ISSN 1440-1584, Vol. 15, no 4, 241-246 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To evaluate the evidence-based use of major drug groups for coronary artery disease (CAD) in patients with chronic heart failure and to identify potential interactions. Design: A retrospective study. Setting: A major non-metropolitan teaching hospital in rural New South Wales. Participants: Includes 24 men and 25 women, with an age average of 77.2 +/- 7.5 years, range 60-96 years. All patients were over 18 years old with CAD and heart failure. Main outcome measures: The evidence-based use of medications and potential drug interactions. Results: On admission, 71% were treated with aspirin/clopidogrel, 71% with angiotensin-converting enzyme inhibitors or angiotensin receptor blocker, 39% with beta-blockers, 29% with short-acting nitrates and 59% with statins. The use of these medications remained unchanged at time of discharge (P > 0.05). Of the 23 patients with hypertension at admission, blood pressure was controlled in seven (30%) before discharge. Potential drug interactions were identified in 37% of the patients. Non-steroidal anti-inflammatory drugs were used in seven (14%) patients. Conclusions: The use of aspirin, angiotensin-converting enzyme inhibitors/angiotensin receptor blocker, beta-blockers, short-acting nitrate and statins in patients with CAD compares favourably with international literatures. However, there is room for improvement in the use of beta-blockers and statins. A greater effort needs to be made to prevent clinically significant drug interactions.

Place, publisher, year, edition, pages
2007. Vol. 15, no 4, 241-246 p.
Keyword [en]
angiotensin-converting enzyme inhibitor, aspirin, beta-blocker, drug interaction, statin
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-112384DOI: 10.1111/j.1440-1584.2007.00902.xISI: 000253902700004PubMedID: 17617087OAI: oai:DiVA.org:uu-112384DiVA: diva2:286089
Available from: 2010-01-13 Created: 2010-01-13 Last updated: 2011-01-11Bibliographically approved

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