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Osteonecrosis following resurfacing arthroplasty: A clinical positron emission tomography study of 14 cases
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
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2009 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 80, no 6, 670-674 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND PURPOSE: One of the main concerns regarding resurfacing arthroplasty is the viability of the remaining part of the femoral head, and the postoperative risk of a femoral neck fracture or collapse. In contrast to radiographic methods, positron emission tomography using the radiotracer [18F]-fluoride (Fluoride-PET) enables us to visualize the viability of bone in the remaining part of the head, despite the presence of the covering metal component. PATIENTS AND METHODS: This is preliminary prospective study of 14 patients who underwent an ASR resurfacing arthroplasty. Apart from clinical and radiographic analyses, all patients were analyzed by PET scan 1 week, 4 months, and 1 year after surgery. RESULTS: 1 patient had a minor region of osteonecrosis on PET scan at 1 week and at 4 months. After 1 year, the necrosis had increased to include most of the head. 2 other patients, normal at 4 months, had developed equally large osteonecrosis at 1 year. A fourth patient had a minor osteonecrosis at 1 year. None of the patients had clinical symptoms, and the necrotic areas were not visible on plain radiographs. CONCLUSIONS: We found Fluoride PET to be a sensitive and useful method for evaluation of bone metabolism at resurfacing arthroplasty. 3 of the 14 patients had developed osteonecrosis, involving most of the head at 1 year. The late onset of the phenomenon does not support the hypothesis of surgically damaged vascularity. The presence of this complication together with the lack of visibility on plain radiographs gives reason for concern.

Place, publisher, year, edition, pages
2009. Vol. 80, no 6, 670-674 p.
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Medical and Health Sciences
Research subject
Orthopaedics
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URN: urn:nbn:se:uu:diva-112493DOI: 10.3109/17453670903278258ISI: 000272611900008PubMedID: 19995317OAI: oai:DiVA.org:uu-112493DiVA: diva2:286172
Available from: 2010-01-14 Created: 2010-01-14 Last updated: 2017-12-12Bibliographically approved

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Milbrink, JanNilsson, OlleSörensen, Jens

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Centre for Research and Development, GävleborgOrthopaedicsDepartment of Medical SciencesSection of Nuclear Medicine and PET
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