Home sampling and pooling of vaginal samples are effective tools for genetic screening of Chlamydia trachomatis among high school female students in Lithuania
2008 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, Vol. 40, no 2, 88-93 p.Article in journal (Refereed) Published
The aims were 1) to estimate the prevalence of C. trachomatis infection among sexually active female students in Kaunas, Lithuania; 2) to investigate the usefulness of personal invitation, self-sampling, and pooling of samples for screening; and 3) to evaluate the costs of the approaches used. A cross-sectional study inviting 795 female students ( 18 - 31 y of age) from 7 high schools and 1 college in Kaunas was performed. The response rate was 67% ( 533/795). Self-obtained vaginal samples were analysed, individually and pooled ( n = 3), using Digene Hybrid Capture II CT/NG Test. The overall prevalence of C. trachomatis infection was 5.6%. Among the sexually active female students 20 - 24 y of age ( n = 424), the prevalence was 7.1%; however, the prevalence varied from 0% to 14.2% at the different schools. For estimation of the population prevalence based solely on identification of C. trachomatis positive pools, the pooling strategy reduced the costs by 85%. For estimation of population prevalence and for diagnosis of each individual sample, pooling reduced the costs by 70%. Targeted screening, using pooling to reduce the expenses, mainly of 3rd and 4th y Lithuanian female students could be recommended. By extended personal contact and internet-based communication, increased participation rates may be attained.
Place, publisher, year, edition, pages
2008. Vol. 40, no 2, 88-93 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-112416DOI: 10.1080/00365540701587002ISI: 000253335800002PubMedID: 17852902OAI: oai:DiVA.org:uu-112416DiVA: diva2:286177