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The bacterial toxin ReIE induces specific mRNA cleavage in the A site of the eukaryote ribosome
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
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2008 (English)In: RNA: A publication of the RNA Society, ISSN 1355-8382, E-ISSN 1469-9001, Vol. 14, no 2, 233-239 p.Article in journal (Refereed) Published
Abstract [en]

ReIE/ReIB is a well-characterized toxin-anti-toxin pair involved in nutritional stress responses in Bacteria and Archae. ReIE lacks any eukaryote homolog, but we demonstrate here that it efficiently and specifically cleaves mRNA in the A site of the eukaryote ribosome. The cleavage mechanism is similar to that in bacteria, showing the feasibility of A-site cleavage of mRNA for regulatory purposes also in eukaryotes. ReIE cleavage in the A-site codon of a stalled eukaryote ribosome is precise and easily monitored, making "ReIE printing" a useful complement to toeprinting to determine the exact mRNA location on the eukaryote ribosome and to probe the occupancy of its A site.

Place, publisher, year, edition, pages
RNA Society , 2008. Vol. 14, no 2, 233-239 p.
Keyword [en]
bacterial toxin ReIE, eukaryotic ribosomes, mRNA cleavage, initiation complex assembly, toeprinting, ReIE printing
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-112436DOI: 10.1261/rna.693208ISI: 000252929400006OAI: oai:DiVA.org:uu-112436DiVA: diva2:286198
Available from: 2010-01-14 Created: 2010-01-13 Last updated: 2017-12-12Bibliographically approved

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Hauryliuk, VasiliEhrenberg, Måns

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