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Effect of fluid shear stress on endocytosis of heparan sulfate and low-density lipoproteins
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2007 (English)In: Journal of Biomedicine and Biotechnology, ISSN 1110-7243, E-ISSN 1110-7251, Vol. 2007Article in journal (Refereed) Published
Abstract [en]

Hemodynamic stress is a critical factor in the onset of atherosclerosis such that reduced rates of shear stress occurring at regions of high curvature are more prone to disease. The level of shear stress has direct influence on the thickness and integrity of the glycocalyx layer. Here we show that heparan sulfate, the main component of the glycocalyx layer, forms an intact layer only on cell surfaces subjected to shear, and not under static conditions. Furthermore, receptor-mediated endocytosis of heparan sulfate and low-density liporoteins is not detectable in cells exposed to shear stress. The internalized heparan sulfate and low-density lipoproteins are colocalized as shown by confocal imaging.

Place, publisher, year, edition, pages
2007. Vol. 2007
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-112449DOI: 10.1155/2007/65136ISI: 000252952300001OAI: oai:DiVA.org:uu-112449DiVA: diva2:286215
Available from: 2010-01-14 Created: 2010-01-13 Last updated: 2010-04-14Bibliographically approved

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