uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
A novel powder sample holder for the determination of glass transition temperatures by DMA
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Show others and affiliations
2009 (English)In: Internation Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 371, no 1-2, 120-125 p.Article in journal (Refereed) Published
Abstract [en]

The use of a new sample holder for dynamic mechanical analysis (DMA) as a means to characterise the Tg of powdered hydroxypropyl methyl cellulose (HPMC) has been investigated. A sample holder was constructed consisting of a rectangular stainless steel container and a lid engineered to fit exactly within the walls of the container when clamped within a TA instruments Q800 DMA in dual cantilever configuration. Physical mixtures of HPMC (E4M) and aluminium oxide powders were placed in the holder and subjected to oscillating strains (1 Hz, 10 Hz and 100 Hz) whilst heated at 3 degrees C/min. The storage and loss modulus signals showed a large reduction in the mechanical strength above 150 degrees C which was attributed to a glass transition. Optimal experimental parameters were determined using a design of experiment procedure and by analysing the frequency dependence of Tg in Arrhenius plots. The parameters were a clamping pressure of 62 kPa, a mass ratio of 0.2 HPMC in aluminium oxide, and a loading mass of either 120 mg or 180 mg. At 1 Hz, a Tg of 177+/-1.2 degrees C (n=6) for powdered HPMC was obtained. In conclusion, the new powder holder was capable of measuring the Tg of pharmaceutical powders and a simple optimization protocol was established, useful in further applications of the DMA powder holder.

Place, publisher, year, edition, pages
2009. Vol. 371, no 1-2, 120-125 p.
Keyword [en]
Amorphous powders, Dynamic mechanical analysis (DMA), Amorphous content, Glass transition, HPMC, Powder holder
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-112916DOI: 10.1016/j.ijpharm.2008.12.039ISI: 000265361300016PubMedID: 19167475OAI: oai:DiVA.org:uu-112916DiVA: diva2:288954
Available from: 2010-01-22 Created: 2010-01-22 Last updated: 2010-07-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Pharmacy
In the same journal
Internation Journal of Pharmaceutics
Pharmaceutical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 198 hits
ReferencesLink to record
Permanent link

Direct link