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Elevated serum concentrations of cobalt, chromium, nickel, and manganese after metal-on-metal alloarthroplasty of the hip: a prospective randomized study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
2009 (English)In: The Journal of Arthroplasty, ISSN 0883-5403, E-ISSN 1532-8406, Vol. 24, no 6, 837-845 p.Article in journal (Refereed) Published
Abstract [en]

In this prospective randomized study, we investigate metal ion concentrations and clinical outcome 2 years after metal-on-metal (28 patients) or metal-on-polyethylene (26 patients) hip arthroplasty with 28-mm modular heads. Metal ion concentrations in patient serum were analyzed by high-resolution plasma mass spectrometry. The clinical outcome was almost identical in both groups with respect to the Harris hip score and the Medical Outcome Study Short Form-36; and on plain radiography, no signs of loosening occurred in any group. In the metal-on-metal group, concentrations of all investigated ions increased significantly when compared with preoperative values: cobalt, 15.3-fold (95% confidence interval [CI], 9.4-21.2); chromium, 5.2-fold (CI, 3.5-7.0); nickel, 2.1-fold (CI, 1.2-3.0); and manganese, 1.6-fold (CI, 1.3-2.0). In the metal-on-polyethylene group, a smaller but significant increase in the concentrations of cobalt and nickel occurred, whereas concentrations of the other ions did not change significantly.

Place, publisher, year, edition, pages
2009. Vol. 24, no 6, 837-845 p.
Keyword [en]
hip arthroplasty, metal ions, metal bearing, metal-on-metal, cobalt, chromium, nickel, manganese
National Category
Medical and Health Sciences
Research subject
URN: urn:nbn:se:uu:diva-113060DOI: 10.1016/j.arth.2008.07.019ISI: 000269607400002PubMedID: 18823744OAI: oai:DiVA.org:uu-113060DiVA: diva2:289460
Available from: 2010-01-25 Created: 2010-01-25 Last updated: 2010-05-31Bibliographically approved

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