Surgical Management of MEN-1 and -2: State of the Art
2009 (English)In: Surgical Clinics of North America, ISSN 0039-6109, Vol. 89, no 5, 1047-1068 p.Article, review/survey (Refereed) Published
Multiple endocrine neoplasia syndrome type 1 (MEN-1) consists of endocrine tumors of the parathyroid, the endocrine pancreas-duodenum, and the pituitary. Surveillance and screening for the endocrinopathies is recommended in gene carriers. Surgery for MEN-1-related hyperparathyroidism is generally performed as radical subtotal parathyroidectomy, because less surgery is likely to result in persistent or recurrent disease. Multiple endocrine neoplasia syndrome type 2 (MEN-2) consists of medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism. Prophylactic thyroidectomy based on DNA testing in the MEN-2 syndrome is considered one of the greater achievements in cancer treatment, because it may be performed before thyroid carcinoma development and provides cure for the patient.
Place, publisher, year, edition, pages
2009. Vol. 89, no 5, 1047-1068 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-113093DOI: 10.1016/j.suc.2009.06.016ISI: 000271782300003PubMedID: 19836484OAI: oai:DiVA.org:uu-113093DiVA: diva2:289657