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Dietary phytosterols inhibit the lipid modulating effects of sesamin in rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
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2007 (English)In: Current Topics in Nutraceutical Research, ISSN 1540-7535, Vol. 5, no 2-3, 93-97 p.Article in journal (Refereed) Published
Abstract [en]

The major lignan in the unsaponifiable fraction of sesame lipids, sesamin, is known to affect lipid metabolism. For example, sesamin inhibits the clearance of tocopherols, the activity of Delta 5-desaturase during fatty acid metabolism, and reduces cholesterol absorption and biosynthesis. In order to study whether dietary phytosterols, which are known to reduce the absorption of lipid soluble dietary factors, may influence the lipid-modulating effects of sesamin, rats were fed, in a 2x2 Latin-square design, diets containing two concentrations of sesamin and pbytosterols for 4 weeks. Tocopherols and cholesterol were analyzed in plasma and liver and the fatty acid profile was determined in liver lipids. Sesamin increased a-tocopherol concentrations in plasma and liver (p< 0. 001), whereas the phytosterols had no effect. However, an increase in the phytosterol content of the diet resulted in a reduction of the alpha-tocopherol-elevating effect of sesamin in plasma (p< 0. 01). Similarly, sesamin increased the percentage of dihomo-gamma-linolenic acid in liver lipids (p<0.05), which was abolished by the addition of pbytosterols. Neither sesamin nor phytosterols significantly altered cholesterol concentrations in plasma or liver. In conclusion, these results suggest that in rats, dietary phytosterols may interact with sesamin in a way reducing its biological activities.

Place, publisher, year, edition, pages
2007. Vol. 5, no 2-3, 93-97 p.
Keyword [en]
cholesterol-lowering, phytosterols, rat, sesamin, tocopherol-elevating
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-113037ISI: 000252031400005OAI: oai:DiVA.org:uu-113037DiVA: diva2:289718
Available from: 2010-01-25 Created: 2010-01-25 Last updated: 2011-03-24Bibliographically approved

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