uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Evidence supporting the use of bone morphogenetic proteins for spinal fusion surgery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
Show others and affiliations
2008 (English)In: Expert review of medical devices, ISSN 1743-4440, Vol. 5, no 1, 75-84 p.Article in journal (Refereed) Published
Abstract [en]

Bone morphogenetic proteins (BMPs) are capable of promoting bone healing and even induce de novo osteogenesis. Their clinical application in spinal fusion surgery has recently increased in popularity. This is especially true for the use of BMPs in combination with artificial bone substitutes that have the capability to replace autologous bone graft, which can be associated with severe harvesting complications. This review will examine the use of BMP-2 and BMP-7 as commercially available products that have proven their osteoinductive capacity in spinal fusion. We will perform an overview of the literature for scientific evidence supporting the use of these new technologies. Despite their high osteoinductive potency, the use of BMPs does not replace proper surgical stabilization in spinal fusion. Safety issues with BMPs are osteoclast activation, postoperative swelling and hyperostosis. Despite these issues, manufacturers continue to expend more effort concerning proper application, dosage and carriers for these devices for spinal fusion, both presently and in the future.

Place, publisher, year, edition, pages
2008. Vol. 5, no 1, 75-84 p.
National Category
URN: urn:nbn:se:uu:diva-113181DOI: 10.1586/17434440.5.1.75PubMedID: 18095899OAI: oai:DiVA.org:uu-113181DiVA: diva2:290084
Available from: 2010-01-26 Created: 2010-01-26 Last updated: 2010-04-21Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Robinson, Yohan
By organisation

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 161 hits
ReferencesLink to record
Permanent link

Direct link