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Reboxetine in therapy-resistant enuresis: a retrospective evaluation
Uppsala Univ, Childrens Hosp, Nephrol Unit.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.ORCID iD: 0000-0002-4590-4957
2009 (English)In: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, E-ISSN 1651-2065, Vol. 43, no 5, 365-368 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Imipramine is the only evidence-based treatment available for enuretic children resistant to standard therapy. The drug's antienuretic effect is probably due to noradrenergic facilitation. The drug is, however, potentially cardiotoxic. In this study, the non-cardiotoxic noradrenergic antidepressant reboxetine was tested as an alternative to imipramine. PATIENTS AND METHODS: 61 patients, aged 7-19 years, with enuresis-resistant to desmopressin, the alarm, urotherapy and anticholinergics, were given 4-8 mg reboxetine at bedtime, if necessary combined with desmopressin. RESULTS: 32 patients became dry on reboxetine treatment, although 21 of them required combination treatment with desmopressin to achieve this. Eighteen children did not respond and eight children discontinued because of side-effects before treatment could be evaluated. No serious adverse events occurred. CONCLUSIONS: These results need to be confirmed with randomized controlled studies, but indicate that reboxetine will become a safe and efficient treatment alternative for enuretic children resistant to standard therapy.

Place, publisher, year, edition, pages
2009. Vol. 43, no 5, 365-368 p.
Keyword [en]
Antidepressants, enuresis, reboxetine
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-113343DOI: 10.3109/00365590903099959ISI: 000272144300004PubMedID: 19921980OAI: oai:DiVA.org:uu-113343DiVA: diva2:290534
Available from: 2010-01-27 Created: 2010-01-27 Last updated: 2016-12-02

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