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Effect of inner ear blood flow changes in Ménière's model mice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2009 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 129, no 3, 244-53 p.Article in journal (Refereed) Published
Abstract [en]

CONCLUSIONS: The endolymphatic sac (ES) is important for inner ear fluid homeostasis. A dysfunctional ES can cause vertigo attacks following additional stress such as a sudden change in endolymphatic volume and/or pressure, or restricted inner ear blood flow. OBJECTIVE: The purpose of this study was to elucidate the mechanism of vertigo attacks in Ménière's disease. MATERIALS AND METHODS: Adult CBA/J mice were given an intratympanic injection of lipopolysaccharide and an intraperitoneal injection of aldosterone. These 'model' animals had epinephrine or sodium nitroprusside (SNP) instilled into the middle ear cavity. Cochleae, vestibules, and endolymphatic sacs were studied morphologically by light microscopy. RESULTS: The injection of epinephrine into the model animals reduced the endolymphatic hydrops in the cochlea, but also produced mild hydrops in the vestibule, which was never observed in untreated (control) animals. The ES did not react to epinephrine in the normal way. Injection of SNP did not cause any changes.

Place, publisher, year, edition, pages
2009. Vol. 129, no 3, 244-53 p.
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-113359DOI: 10.1080/00016480802241980ISI: 000263553200004PubMedID: 18615328OAI: oai:DiVA.org:uu-113359DiVA: diva2:290588
Available from: 2010-01-27 Created: 2010-01-27 Last updated: 2017-12-12Bibliographically approved

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