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Changes in transient receptor potential vanilloid (TRPV) 1, 2, 3 and 4 expression in mouse inner ear following gentamicin challenge
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2009 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 129, no 2, 116-26 p.Article in journal (Refereed) Published
Abstract [en]

CONCLUSION: It is suggested that transient receptor potential vanilloid (TRPV)-1 and -2 may be of pathological significance for sensory cells and ganglions, while TRPV-3 and -4 may play an important part in neuroprotection of the inner ear. OBJECTIVE: Changes in the expression of TRPV-1, -2, -3, and -4 in gentamicin (GM)-treated mouse inner ear were studied. MATERIALS AND METHODS: CBA/J mice were used in this study. The localization of TRPV-1, -2, -3, and -4 in the inner ear of both untreated and GM-treated CBA/J animals (intratympanic injection of 5 mg GM) was investigated by immunohistochemistry. RESULTS: TRPV-1, -2, and -3 were co-expressed in the inner ear sensory and ganglion cells, while TRPV-4 was also expressed in the stria vascularis and vestibular dark cells. Following GM treatment, the intensity of immunofluorescent reaction to TRPV-1 and TRPV-2 increased, while that to TRPV-3 and TRPV-4 decreased.

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2009. Vol. 129, no 2, 116-26 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-113360DOI: 10.1080/00016480802032835ISI: 000262508000001PubMedID: 18607956OAI: oai:DiVA.org:uu-113360DiVA: diva2:290592
Available from: 2010-01-27 Created: 2010-01-27 Last updated: 2017-12-12Bibliographically approved

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Anniko, Matti

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Otolaryngology and Head and Neck Surgery
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