Protective effect of edaravone against tobramycin-induced ototoxicity
2009 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 129, no 1, 8-13 p.Article in journal (Refereed) Published
CONCLUSION: It is suggested that simultaneous treatment with the radical scavenger edaravone has an effective protective effect against tobramycin ototoxicity in rat. Even if the edaravone treatment is postponed for 7 days, it can still prevent hearing loss, but a 14 day delay cannot protect from ototoxicity. OBJECTIVES: With the aim of alleviating hearing loss caused by aminoglycoside ototoxicity, we performed a trial to assess the hearing protective efficacy of the radical scavenger edaravone. MATERIALS AND METHODS: In part one of the study, 21 male Sprague-Dawley albino rats were used; 2 rats served as controls for the safety of edaravone. Eight rats each received 10 subcutaneous injections (s.c.) of tobramycin (160 mg/kg b.w.) once daily and saline injection intraperitoneally for 2 weeks. Eleven rats were given 10 s.c. tobramycin injections simultaneously with an intraperitoneal injection of edaravone (3 mg/kg b.w.). In part two, tobramycin was injected in 13 rats (as above). Five of these received two edaravone injections 7 days later and four rats similarly 14 days later. Auditory brainstem response (ABR) was used to assess hearing. RESULTS: All rats treated only with tobramycin showed a deterioration of hearing. None of the rats given simultaneous treatment with tobramycin and edaravone demonstrated hearing loss. A 7 day delay in edaravone injection still prevented hearing loss, but a 14 day delay had only a temporary prophylactic effect.
Place, publisher, year, edition, pages
2009. Vol. 129, no 1, 8-13 p.
Animal, rat, auditory brainstem response, edaravone, aminogycoside, hearing loss, cochlear ototoxicity, cochlear protection, reactive oxygen species, antioxidant
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-113361DOI: 10.1080/00016480802008199ISI: 000261847700002PubMedID: 18607936OAI: oai:DiVA.org:uu-113361DiVA: diva2:290593