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Association of TNF-α serum levels and TNFA promoter polymorohisms with risk of myocardial infarction
Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm.
Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Preventive Medicine.
Unit of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
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2006 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 187, no 2, p. 408-414Article in journal (Refereed) Published
Abstract [en]

Elevated levels of tumor necrosis factor-alpha (TNF-α), and presence of polymorphisms of the TNFA gene have been implicated in cardiovascular disease pathogenesis. We explored the relationship between polymorphisms in the TNFA gene (−1031C/T, −863C/A −857T/C, −308G/A, −238G/A), protein levels of TNF-α and their association to myocardial infarction (MI) using a sample of 1213 post-MI patients and 1561 healthy controls. MI risk was higher among men with elevated TNF-α levels, with the highest compared to the lowest TNF-α quartile giving a 70% risk increase (OR [95% CI]: 1.7 [1.1; 2.6]). Obese subjects who also had elevated TNF-α levels were at even higher risk for MI (OR [95% CI]: 3.4 [2.1; 5.6]). Higher TNF-α levels were seen among smokers (but not among non-smokers) carrying the −857T allele. Furthermore, a rare haplotype occurred more frequently among the cases than the controls. Elevated TNF-α levels are associated with increased MI risk. Obese subjects with elevated TNF-a levels, and carriers of polymorphisms in or near TNFA are particularly susceptible to the hazards of smoking, results which may have implications for cardiovascular preventive measures.

Place, publisher, year, edition, pages
Elsevier , 2006. Vol. 187, no 2, p. 408-414
Keyword [en]
Tumor necrosis factor-alpha, Myocardial infarction, Epidemiology, Single nucleotide polymorphisms, Risk factors
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-113386DOI: 10.1016/j.atherosclerosis.2005.09.022PubMedID: 16243340OAI: oai:DiVA.org:uu-113386DiVA, id: diva2:290723
Available from: 2010-01-28 Created: 2010-01-28 Last updated: 2017-12-12Bibliographically approved

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