Effect of inner ear blood flow changes on the endolymphatic sac
2008 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 128, no 11, 1187-95 p.Article in journal (Refereed) Published
CONCLUSIONS: That the endolymphatic sac (ES) reacts to changes in inner ear blood flow may be important for homeostasis of the inner ear fluid volume and pressure. OBJECTIVES: To elucidate the effect of changes in inner ear blood flow on the ES and to learn more about the volume and pressure regulatory function of the ES. MATERIALS AND METHODS: Epinephrine or sodium nitroprusside (SNP) was injected into the middle ear cavity of adult CBA/J mice. The ES were analyzed morphologically by light microscopy. RESULTS: Epinephrine reduced the luminal size of the ES leading to an accumulation of intraluminal homogeneous substance. Injection of SNP increased the size of the ES lumen, accompanied by a collapse of the lateral intercellular space (LIS) and dense perisaccular tissue. These changes were almost reversed 4 h after injection.
Place, publisher, year, edition, pages
2008. Vol. 128, no 11, 1187-95 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-113594DOI: 10.1080/00016480801910387ISI: 000260032900004PubMedID: 18607967OAI: oai:DiVA.org:uu-113594DiVA: diva2:291327