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Effect of inner ear blood flow changes on the endolymphatic sac
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2008 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 128, no 11, 1187-95 p.Article in journal (Refereed) Published
Abstract [en]

CONCLUSIONS: That the endolymphatic sac (ES) reacts to changes in inner ear blood flow may be important for homeostasis of the inner ear fluid volume and pressure. OBJECTIVES: To elucidate the effect of changes in inner ear blood flow on the ES and to learn more about the volume and pressure regulatory function of the ES. MATERIALS AND METHODS: Epinephrine or sodium nitroprusside (SNP) was injected into the middle ear cavity of adult CBA/J mice. The ES were analyzed morphologically by light microscopy. RESULTS: Epinephrine reduced the luminal size of the ES leading to an accumulation of intraluminal homogeneous substance. Injection of SNP increased the size of the ES lumen, accompanied by a collapse of the lateral intercellular space (LIS) and dense perisaccular tissue. These changes were almost reversed 4 h after injection.

Place, publisher, year, edition, pages
2008. Vol. 128, no 11, 1187-95 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-113594DOI: 10.1080/00016480801910387ISI: 000260032900004PubMedID: 18607967OAI: oai:DiVA.org:uu-113594DiVA: diva2:291327
Available from: 2010-02-01 Created: 2010-02-01 Last updated: 2010-02-10Bibliographically approved

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