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Serum S-100B protein levels in patients with herpes simplex encephalitis and tick-borne encephalitis: a marker of CNS damage during the initial stage of disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
2009 (English)In: Journal of Neurology, ISSN 0340-5354, E-ISSN 1432-1459, Vol. 256, no 4, 586-590 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND PURPOSE: This study was mainly aimed at the comparative analysis of serum S-100B protein in patients with herpes simplex encephalitis (HSE) and tick-borne encephalitis (TBE). S-100B protein is an established biochemical marker of astroglial damage in central nervous system (CNS) injury. METHODS: Serum levels of S-100B were measured using a commercial immunolumino-metric assay (LIA). RESULTS: Patients with HSE (n = 17) had significantly higher levels of S-100B with median 0.351 microg/l (range 0.017-0.636) compared to patients with TBE (n = 15), who had 0.04 microg/l (range 0.001-0.542) (p < 0.001), as well as controls (n = 17) 0.054 (range 0.004-0.214) (p < 0.001). 11/17 patients with HSE had serum S-100B levels above 0.2 microg/l, in contrast to 1/15 patients with TBE and 1/17 of the control patients. The patients with HSE with serum levels below 0.2 microg/l had a mean 3.2 days disease duration, while patients with levels above 0.2 microg/l had 6 days disease duration. CONCLUSIONS: The serum levels of S-100B in the acute stage of disease were significantly higher in patients with HSE than in patients with TBE or controls. A role for the use of serum S-100B in monitoring CNS damage during initial stage of disease in HSE is suggested.

Place, publisher, year, edition, pages
2009. Vol. 256, no 4, 586-590 p.
Keyword [en]
serum S-100B protein, herpes simplex encephalitis, tick-borne encephalitis
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-113850DOI: 10.1007/s00415-009-0124-yISI: 000266091300008PubMedID: 19367359OAI: oai:DiVA.org:uu-113850DiVA: diva2:292006
Available from: 2010-02-04 Created: 2010-02-04 Last updated: 2010-07-28Bibliographically approved

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