A randomized study comparing short-time infusion of oxaliplatin in combination with capecitabine XELOX(30) and chronomodulated XELOX(30) as first-line therapy in patients with advanced colorectal cancer
2010 (English)In: Annals of Oncology, ISSN 0923-7534, E-ISSN 1569-8041, Vol. 21, no 1, 87-91 p.Article in journal (Refereed) Published
BACKGROUND: Chronotherapy is one of the several approaches to increase efficacy and reduce toxicity of chemotherapy. In a phase II study in the second-line in patients with metastatic colorectal cancer (mCRC), we found that chronomodulated XELOX (XELOX(30Chron)) was a well-tolerated regimen with potentially reduced toxicity. PATIENTS AND METHODS: One hundred and forty-one patients with unresectable mCRC were enrolled in a randomized study comparing standard XELOX (XELOX(30)), arm A, and XELOX(30Chron), arm B-both with short-time infusion of oxaliplatin-with the primary aim of reducing overall toxicity. RESULTS: Overall toxicity grade 2-4 was 90% versus 85%, P = 0.47 and grade 3-4 was 31% versus 37%, P = 0.6 in arm A and B, respectively. We found no significant differences in median overall survival (17.6 versus 15.5 months; P = 0.068) and median progression-free survival (8.9 versus 8.8 months; P = 0.7). The incidence of grade 3 neuropathy was 16% in arm A and 19% in arm B (P = 0.7) after a cumulative dose of oxaliplatin of 1000 mg/m(2). CONCLUSION: XELOX(30Chron) does not reduce toxicity or improve efficacy. A 30-min infusion of oxaliplatin is safe and does not increase the severity of chronic neuropathy.
Place, publisher, year, edition, pages
2010. Vol. 21, no 1, 87-91 p.
capecitabine, chronotherapy, colorectal cancer, oxaliplatin, randomized, short-time infusion
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-113890DOI: 10.1093/annonc/mdp272ISI: 000272924300014PubMedID: 19622596OAI: oai:DiVA.org:uu-113890DiVA: diva2:292104