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The importance of scavenging reactive oxygen species in angi-aging medicine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
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2009 (English)In: Engineering in Life Sciences, ISSN 1618-0240, E-ISSN 1618-2863, Vol. 9, no 5, 363-375 p.Article in journal (Refereed) Published
Abstract [en]

 In a pilot Study, we had reported on the beneficial effects of Ginkgo   biloba (EGb 761) on arteriosclerotic nanoplaque formation and size in   cardiovascular high-risk patients who had undergone an aortocoronary   bypass operation. Briefly, nanoplaque formation and size, the ratio   oxLDL/LDL, and the highly atherothrombotic lipoprotein(a) concentration   were substantially reduced, while superoxide dismutase activity and the   blood concentration of the vasodilating substances cAMP and cGMP were   Upregulated. Since the arteriosclerosis prophylactic and well-aging   promotive impact of Ginkgo extract has been proven in this pilot study,   we wanted to confirm these beneficial effects through a second   observational clinical trial. The measurable variables formerly used   were additionally supplemented by a wide, novel biomarker spectrum,   through which the latest parameters and markers of plaque stability and   progression, oxidative stress, and inflammation were available. In   eleven patients with metabolic syndrome in the initial stage, the   reduction of arteriosclerotic nanoplaque formation amounted to 14.3 +/-   2.9% (p<0.0077) and of nanoplaque size to 23.4 +/- 3.7% (p<0.0004),   respectively, after 2-(SOD) and glutathione peroxidase (GPx) activities   were upregulated by 19.6 +/- 10.0% (p<0.0785) and 11.6 +/- 2.3%   (p<0.001), respectively, the quotient oxLDL/LDL lowered by 21.0 +/-   4.3% (p<0.002), and lipoprotein(a) concentration decreased by 26.3 +/-   4.8% (p<0.001) in the patients' blood. The concentration of cAMP and   cGMP was augmented by 43.5 +/- 12.0% (p<0.001) and 32.9 +/- 10.4%   (p<0.001), respectively. Surprisingly, we found a lowering of the serum   Ca2+ concentration by 5.4 +/- 1.6% (p<0.0076) from 2.37 +/- 0.03 to   2.24 +/- 0.04 mmol/L (p<0.0069). Apart from an additional vasodilatory   effect, the lowered extracellular Ca2+ concentration affects Could show   a favourable development of the biomarkers 8-iso-PGF(2 alpha),   oxLDL/LDL, SOD, GPx (oxidative stress), hs-CRP, MPO, TNF alpha TGF   beta(1) (inflammatory status) and MMP-9 (plaque stability). The markers   selected here are suited to provide a comprehensive risk profile for   the prevention of arteriosclerosis. Finally, a multiple regression   analysis reveals a basis for a mechanistic explanation of nanoplaque   reduction under Ginkgo treatment. The arteriosclerosis inhibiting   effect is due to an attenuation of the risk factors oxLDL/LDL, Lp(a),   and [Ca2+](o) as well as to a significant increase in the vasodilator   cAMP and cGMP concentration. Thus, Ginkgo with its pleiotropic effects   should be assigned a fixed rank among the anti-aging medical   therapeutics as a prophylactic measure, especially in patients with   early-stage metabolic syndrome.

Place, publisher, year, edition, pages
2009. Vol. 9, no 5, 363-375 p.
Keyword [en]
Clinical trial, Ellipsometry, Ginkgo biloba, Metabolic syndrome
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-113933DOI: 10.1002/elsc.200800112ISI: 000272207800002OAI: oai:DiVA.org:uu-113933DiVA: diva2:292203
Available from: 2010-02-05 Created: 2010-02-05 Last updated: 2010-06-23Bibliographically approved

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