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Ellipsometry studies of lipoprotein adsorption as a biosensor tool in atherosclerosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2009 (English)In: Journal of Dispersion Science and Technology, ISSN 0193-2691, E-ISSN 1532-2351, Vol. 30, no 6, 795-801 p.Article in journal (Refereed) Published
Abstract [en]

Lipoprotein adsorption was investigated at a range of surfaces by in situ ellipsometry, with the aim of reaching a better understanding of  its possibilities and limitations as a biosensor tool in the context of atherosclerosis. Although ellipsometry allows direct investigation of   lipoprotein interfacial deposition at surfaces coated with confluent layers of endothelial cells, that is, essentially the full biological  system equivalent, a simpler and more robust model system based on proteoheparan sulfate adsorbed via its membrane-anchoring domain at hydrophobic surfaces was found to provide largely the same information. While simplistic, it was found that Ca2+-induced adsorption of a range of lipoproteins involved in atherosclerosis at surfaces coated with proteoheparan sulfate indeed provides some accelerated information on initial atherosclerotic plaque formation, as evidenced by correlations between lipoprotein adsorption and well known clinical effects of  lipoprotein composition and of treatment with anti-atherosclerotic drugs of synthetic as well as natural origin.

Place, publisher, year, edition, pages
2009. Vol. 30, no 6, 795-801 p.
Keyword [en]
Asorption, atheroschlerosis, ellipsometry, lipoprotein, plaque, proteoglycan, proteoheparan sulfate
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-113937DOI: 10.1080/01932690802643337ISI: 000266436200008OAI: oai:DiVA.org:uu-113937DiVA: diva2:292217
Available from: 2010-02-05 Created: 2010-02-05 Last updated: 2010-07-27Bibliographically approved

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